Robert Vaughn died surrounded by his family on Friday morning, his manager, Matthew Sullivan, confirmed to ABC News.
Sullivan added that Vaughn, who was most famous for starring in the series "The Man From U.N.C.L.E," had been battling acute leukemia for one year.
He was 83 years old.
Vaughn was “a real gentleman," Sullivan said.
Vaughn, a native New Yorker who grew up in Minnesota, was nominated for an Academy Award in 1960 for his role in "The Young Philadelphians." He also appeared in the classic film "The Magnificent Seven." However, it was his starring role in "The Man From U.N.C.L.E." that made him famous.
In the show, Vaughn's Napoleon Solo teams up with Russian spy Illya Kuryakin, played by David McCallum, to work for the secret espionage agency U.N.C.L.E., which stood for United Network Command for Law and Enforcement. James Bond creator Ian Fleming came up with a few concepts for the show, including the name "Napoleon Solo."
In 2015, a big-screen version of the show, starring Henry Cavill as Solo, arrived in theaters.
Throughout his decades-long career, Vaughn also appeared in TV shows including "The Protectors," "The A-Team," and more recently, two British TV series, "Hustle" and "Coronation Street." He was also a prolific movie actor, appearing in films ranging from the 1970 classic "Julius Caesar" to the 2001 comedy "Pootie Tang."
Vaughn is survived by Linda, his wife of more than four decades, and their two children, Cassidy and Caitlin.